ZFIN Image: Dee et al., 2008, Fig. 2

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Figure Caption

Fig. 2 Sox3 over-expression causes expansion of the neural plate. All embryos are viewed from the dorsal side at the 3-somite stage. Markers for in situ hybridisation are indicated. (A–F) Wild-type controls. (G–L) Embryos co-injected with sox3 mRNA and GFP mRNA (lineage tracer) at 16–32 cell stage. (M–R) The same embryos immunostained to detect the GFP protein (red colour). Sox3 over-expression causes neural plate markers ncad and sox2 to expand locally (G, M, 29/47 embryos, H, N, 32/39). Markers of the neural crest; foxd3 (I, O, 12/30) and snai1b (J, P, 22/39) and pre-placodal ectoderm; pax2a (K, Q, 14/30) and pax8 (L, R, 16/32) are displaced laterally.

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Acknowledgments

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Reprinted from Developmental Biology, 320(1), Dee, C.T., Hirst, C.S., Shih, Y.H., Tripathi, V.B., Patient, R.K., and Scotting, P.J., Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm, 289-301, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.