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Fig. 5 olig3 mediates mediolateral specification. isl2 staining of RB cells is shown. RB cells originating in the neural crest domain are increased in number in olig3MO-injected embryos (morphant isl2 phenotype > 90%, n = 20) (b) as well as in DAPT-treated embryos (morphant isl2 phenotype > 90%, n = 40) (c) compared with controls (a). DAPT treatment and olig3MO act synergistically (d) (morphant isl2 phenotype > 90%, n = 20). Embryos are shown in dorsal view with anterior to the left.
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