Gene

isl2a

ID

ZDB-GENE-980526-562

Name

ISL LIM homeobox 2a

Symbol

isl2a Nomenclature History

Previous Names

isl2
zfIsl-2
wu:fc29g02

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in blood vessel morphogenesis; exocrine pancreas development; and neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including ectoderm; gut; liver and biliary system; nervous system; and neural tube. Orthologous to human ISL2 (ISL LIM homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

91 figures from 60 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu308 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With isl2a Human Ortholog

No data available

Associated With isl2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR047244	Insulin gene enhancer protein ISL-1/2-like, LIM domain1
Family	IPR047169	Insulin gene enhancer protein ISL-1/2-like
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeobox, conserved site	Homeodomain	Insulin gene enhancer protein ISL-1/2-like	Insulin gene enhancer protein ISL-1/2-like, LIM domain1	Zinc finger, LIM-type
UniProtKB:A0A8M2BA75 InterPro	360
UniProtKB:A0A8M9PML2 InterPro	257
UniProtKB:A0A8M9PGP9 InterPro	337
UniProtKB:B3DH43 InterPro	359
UniProtKB:P53406 InterPro	359

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	isl2a-201 (1) Ensembl	Ensembl		1,686 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-isl	monoclonal	isl1a isl2a	IgG1	Mouse	IHC	Developmental Studies Hybridoma Bank	26
Ab2-isl	monoclonal	isl1a isl2a	IgG2b	Mouse	IHC	Developmental Studies Hybridoma Bank	142

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations