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Fig. 3 Insulin expression in hh signal transduction mutants. Insulin expression in 48-hpf WT (A), homozygous yotty17a-/- (B) and smub577-/- embryos (C). Arrows denote the presence of insulin-labeled cells in the mutants (B, C).
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Reprinted from Developmental Biology, 244(1), diIorio, P.J., Moss, J.B., Sbrogna, J.L., Karlstrom, R.O., and Moss, L.G., Sonic hedgehog is required early in pancreatic islet development, 75-84, Copyright (2002) with permission from Elsevier. Full text @ Dev. Biol.