ZFIN Image: Park et al., 2002, Fig. 5

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Figure Caption

Fig. 5 olig2 promotes primary motor neuron development. (A-C) Side views of 20-hpf embryos hybridized with isl2 probe. (A) Normal distribution of one to two primary motor neurons per ventral spinal cord (sc) hemisegment (arrows) and dorsal Rohon-Beard neurons (RB). (B) Embryo injected with olig2 MO lacked primary motor neurons but had Rohon-Beard neurons. (C) Embryo injected with olig2 mRNA. Excess primary motor neurons developed in ventral spinal cord (arrows), whereas Rohon-Beard neurons appeared normal. Apparent differences in Rohon-Beard cell number reflect normal variation and difference in depth of optical section. (D-F) Transverse sections of embryos hybridized with lim1 RNA probe. lim1-expressing cells appeared normal in embryos injected with olig2 MO (E) or olig2 mRNA (F). Scale bar, 20 μm for all panels.

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Acknowledgments

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Reprinted from Developmental Biology, 248(2), Park, H.-C., Mehta, A., Richardson, J.S., and Appel, B., olig2 is required for zebrafish primary motor neuron and oligodendrocyte development, 356-368, Copyright (2002) with permission from Elsevier. Full text @ Dev. Biol.