ZFIN Image: Amack et al., 2007, Fig. 3

Image

Figure Caption

Fig. 3 Asymmetric gene expression is initiated randomly in ntl and tbx16 mutants. (A–C) At 10–12 SS spaw is normally expressed in a symmetric ‘perinodal’ domain flanking KV (arrow in panel A) and is just being initiated asymmetrically in left LPM (arrowhead in panel A). All views are dorsal; left (L) and right (R) sides are indicated in panel A. In both ntl and tbx16 mutant embryos, perinodal spaw expression was greatly reduced or absent (arrow in panels B, C) and LPM expression was left-sided, right-sided (arrowhead in panels B and C) or bilateral (see Table 1). (D–F) At 17–19 SS spaw remained left-sided in wild-type embryos (D) and randomized in tbx16 mutants (E), but was bilateral in all ntl mutants (F) (see Table 1). (G–I) The nodal antagonist charon is expressed around KV in wild-type embryos (arrow in panel G) and tbx16 mutants (arrow in panel H), but is reduced or absent in ntl mutant embryos (arrow in panel I).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 310(2), Amack, J.D., Wang, X., and Yost, H.J., Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish, 196-210, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.