Fig. 4

Fig. 4 Fig. 4. Ace^ti282a/+ zebrafish exhibit aberrant craniofacial geometry. A relative warp analysis revealed two principal component axes that discriminate ace^ti282a/+ zebrafish from their wild-type siblings (A). The inset illustrates the position of fourteen landmarks used to describe the craniofacial skeleton in the lateral view. (B), Deformation grids as a function of the axes that differentiate ace^ti282a/+ and +/+ individuals. Ace^ti282a/+ animals exhibited an expanded frontal region of the skull (purple triangle), relative to the length of the posterior region of the cranium (green line). Ace^ti282a/+ zebrafish also exhibited coordinated changes in the configuration of the upper jaws (blue triangle), and in the relative height of the skull (yellow line).