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Fig. 4
Nkds inhibit late canonical Wnt/β-catenin signaling. (A, B) Standard 1 to 2 cell overexpression of nkd1 or nkd2a RNA significantly expands gsc expression at 50% epiboly (B) compared with uninjected control siblings (A). (C) Injection of nkd1 MO, nkd2 MO and nkd1 or nkd2a RNA that is insensitive to the MOs results in an even larger expansion of gsc expression at 50%. (A–C) Dorsal view. This data is quantified in panel D. Error bars represent standard deviation (Students t-test, *, p < 0.05; ***, p < 0.0001).
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Reprinted from Developmental Biology, 309(2), Van Raay, T.J., Coffey, R.J., and Solnica-Krezel, L., Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling, 151-168, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.