|
Fig. 6 The foxe3 morphants display reduced eye and pupil size. The foxe3 morphants (panels D-F) are compared to uninjected (panels A–C) and mismatch control morpholino-injected embryos (panels G–I) at 3, 4 and 5 dpf. At 3 dpf, the eyes of the foxe3 morphants (panel D) are slightly reduced in size compared to the controls (panels A and G). At 4 dpf, small pupils also characterize the morphants (compare panel E to panels B and H). The eyes of some morphants lacked a pupillary opening at 5 dpf (compare panel F to panels C and I). The distribution of eye dimensions that were measured along the anterior-posterior axis (length) and dorsal–ventral axis (width) of uninjected control and foxe3 morphants (5 dpf) are shown in panel J. The distributions of control and foxe3 morphant pupil dimensions are also shown (panel K).
Reprinted from Mechanisms of Development, 123(10), Shi, X., Luo, Y., Howley, S., Dzialo, A., Foley, S., Hyde, D.R., and Vihtelic, T.S., Zebrafish foxe3: Roles in ocular lens morphogenesis through interaction with pitx3, 761-782, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.