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Fig. S4 Persistent expression of col2a1 by notochord vacuolar cells after lysyl oxidase inhibition is not due to mechanical distortion of the notochord. Wild-type embryos incubated with (B) or without (A) 2 μM neocuproine were probed for col2a1 expression at 24 hpf. col2a1 expression persists in the notochord vacuolar cells after treatment with 2 μM neocuproine, which affects crosslinking but does not cause mechanical distortion. This suggests that the signal to downregulate col2a1 expression in the vacuolar cells of the notochord originates from the products of the crosslinking reaction.
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Reprinted from Developmental Biology, 307(2), Gansner, J.M., Mendelsohn, B.A., Hultman, K.A., Johnson, S.L., and Gitlin, J.D., Essential role of lysyl oxidases in notochord development, 202-213, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.