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Fig. 4 Lysyl oxidases are expressed by notochord vacuolar cells. (A–D) Frozen cross-sections of 15 somite embryos were obtained after in situ hybridization with the following probes: (A) loxl1; (B) loxl2b; (C) loxl3b; and (D) loxl5b. The notochord is indicated (arrowheads). Hypochord staining of loxl1 (arrows) suggests a role for this family member in extracellular matrix crosslinking near the developing aorta. (E) Cartoon demonstrating the location of the hypochord (h) and floorplate (f), which are closely apposed to the notochord (n). Lysyl oxidases are not expressed in the floorplate.
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Reprinted from Developmental Biology, 307(2), Gansner, J.M., Mendelsohn, B.A., Hultman, K.A., Johnson, S.L., and Gitlin, J.D., Essential role of lysyl oxidases in notochord development, 202-213, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.