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Fig. 3 IGF1Rb is required for normal PGC migration. Ectopic PGCs (arrows) were detected rarely in control-MO-injected embryos (A), whereas they were frequently observed, in both somatic tissues (B) and throughout the yolk cell (C) of igf1rb-MO-injected embryos. (D) Mean numbers of ectopic PGCs in zebrafish embryos after morpholino injections, and/or overexpression of an antiapoptotic Bcl2-like protein (Bcl2l). Data represent means ± SEM, with sample size indicated in parentheses. Superscript letters denote significant differences between groups (ANOVA, Tukey's, P < 0.05). Magnification (A–C), 200x.
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Reprinted from Developmental Biology, 305(1), Schlueter, P.J., Sang, X., Duan, C., and Wood, A.W., Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival, 377-387, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.