Gene
ddx4
- ID
- ZDB-GENE-990415-272
- Name
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
- Symbol
- ddx4 Nomenclature History
- Previous Names
-
- vas
- vasa
- vlg
- wu:fi24g05
- zgc:109812
- zgc:158535
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable RNA helicase activity and mRNA binding activity. Acts upstream of or within germ cell development; gonad development; and regulation of meiotic cell cycle. Located in P granule. Is expressed in several structures, including blastodisc; germ line cell; reproductive system; shield; and unfertilized egg. Orthologous to human DDX4 (DEAD-box helicase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 180 figures from 101 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Hartung et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000629 | ATP-dependent RNA helicase DEAD-box, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014014 | RNA helicase, DEAD-box type, Q motif |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent RNA helicase DEAD-box, conserved site | DEAD/DEAH box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA helicase, DEAD-box type, Q motif |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:O42107 | InterPro | 716 | ||||||
| UniProtKB:A0A8M9PTC4 | InterPro | 700 | ||||||
| UniProtKB:A0A8M6Z2W1 | InterPro | 714 | ||||||
| UniProtKB:A0A8M6Z8Q8 | InterPro | 704 | ||||||
| UniProtKB:A0A8M9Q5S2 | InterPro | 699 | ||||||
| UniProtKB:Q8QGG8 | InterPro | 715 | ||||||
| UniProtKB:A0A8M9QBU4 | InterPro | 688 | ||||||
| UniProtKB:A0A8M9QKJ0 | InterPro | 687 | ||||||
| UniProtKB:A0AB32TXW6 | InterPro | 687 | ||||||
| UniProtKB:A0AB32U0J5 | InterPro | 699 |
Interactions and Pathways
No data available
Plasmids