|
Fig. 1 Clustal alignment of predicted amino acid sequences of Tcf7 in zebrafish (Danio rerio, D.r.), Xenopus laevis (X.l.), mouse (Mus musculus, M.m.), and human (Homo sapiens, H.s.). The amino acid sequences are 53%, 49%, and 46% identical to zebrafish Tcf7 B isoform, respectively. A: Amino acid alignment up to the point of alternative C-termini (amino acid #400). Highlighted are the amino terminal β-catenin binding domain, the putative Groucho binding domain, and the C-terminal HMG box. The mouse form shown does not include the Groucho binding domain; however, other splice forms do. B: Amino acid alignments of C-terminal Tcf7 splice forms corresponding to the human B, C, and D isoforms share significant amino acid identity.