Gene

tcf7l1b

ID

ZDB-GENE-991110-10

Name

transcription factor 7 like 1b

Symbol

tcf7l1b Nomenclature History

Previous Names

tcf3b (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell proliferation in dorsal spinal cord; endothelial cell fate specification; and nervous system development. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Is expressed in nervous system; optic vesicle; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf7l1b Human Ortholog

No data available

Associated With tcf7l1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Domain	IPR013558	CTNNB1 binding, N-teminal
Family	IPR024940	Transcription factor TCF/LEF
Homologous_superfamily	IPR027397	Catenin binding domain superfamily
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	Catenin binding domain superfamily	CTNNB1 binding, N-teminal	High mobility group box domain	High mobility group box domain superfamily	Transcription factor TCF/LEF
UniProtKB:Q800Q5 InterPro	551
UniProtKB:F1R336 InterPro	550

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tcf7l1b-201 (1) Ensembl	Ensembl	4,356 nt	Select Tool ZFIN BLAST
mRNA	tcf7l1b-202 (1) Ensembl	Ensembl	3,042 nt	Select Tool ZFIN BLAST
mRNA	tcf7l1b-203 (1) Ensembl	Ensembl	1,040 nt	Select Tool ZFIN BLAST
mRNA	tcf7l1b-204 (1) Ensembl	Ensembl	3,711 nt	Select Tool ZFIN BLAST
mRNA	tcf7l1b-205 (1) Ensembl	Ensembl	4,461 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations