Gene
mdka
- ID
- ZDB-GENE-990621-1
- Name
- midkine a
- Symbol
- mdka Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity. Involved in regulation of cell cycle. Acts upstream of with a positive effect on positive regulation of mitotic cell cycle. Acts upstream of or within neural tube formation and sensory epithelium regeneration. Located in Golgi apparatus. Is expressed in several structures, including brain; eye; neural tube; neuroectoderm; and paraxial mesoderm. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020089 | Pleiotrophin/Midkine, N-terminal domain |
| Domain | IPR020090 | Pleiotrophin/Midkine, C-terminal domain |
| Family | IPR000762 | Midkine heparin-binding growth factor |
| Homologous_superfamily | IPR020091 | Pleiotrophin/Midkine disulphide-rich domain superfamily |
| Homologous_superfamily | IPR037122 | Pleiotrophin/Midkine, N-terminal domain superfamily |
| Homologous_superfamily | IPR038130 | Pleiotrophin/Midkine, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Midkine heparin-binding growth factor | Pleiotrophin/Midkine, C-terminal domain | Pleiotrophin/Midkine, C-terminal domain superfamily | Pleiotrophin/Midkine disulphide-rich domain superfamily | Pleiotrophin/Midkine, N-terminal domain | Pleiotrophin/Midkine, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9W767
|
146 |
Interactions and Pathways
No data available
Plasmids