Gene
mdka
- ID
- ZDB-GENE-990621-1
- Name
- midkine a
- Symbol
- mdka Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity. Acts upstream of with a positive effect on positive regulation of mitotic cell cycle. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; neural tube formation; and sensory epithelium regeneration. Located in Golgi apparatus. Is expressed in several structures, including heart; nervous system; neural tube; neuroectoderm; and paraxial mesoderm. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020089 | Pleiotrophin/Midkine, N-terminal domain |
| Domain | IPR020090 | Pleiotrophin/Midkine, C-terminal domain |
| Family | IPR000762 | Midkine heparin-binding growth factor |
| Homologous_superfamily | IPR020091 | Pleiotrophin/Midkine disulphide-rich domain superfamily |
| Homologous_superfamily | IPR037122 | Pleiotrophin/Midkine, N-terminal domain superfamily |
| Homologous_superfamily | IPR038130 | Pleiotrophin/Midkine, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Midkine heparin-binding growth factor | Pleiotrophin/Midkine, C-terminal domain | Pleiotrophin/Midkine, C-terminal domain superfamily | Pleiotrophin/Midkine disulphide-rich domain superfamily | Pleiotrophin/Midkine, N-terminal domain | Pleiotrophin/Midkine, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9W767
|
146 |
Interactions and Pathways
No data available
Plasmids