Gene
cyp19a1a
- ID
- ZDB-GENE-990415-43
- Name
- cytochrome P450, family 19, subfamily A, polypeptide 1a
- Symbol
- cyp19a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including primary sex determination, germ-line; regulation of estrogen biosynthetic process; and response to estradiol. Predicted to localize to integral component of membrane. Used to study disorders of sexual development. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Is expressed in several structures, including eye; female organism; granulosa cell; male organism; and reproductive system. Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 87 figures from 61 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aromatase excess syndrome | Alliance | Aromatase excess syndrome | 139300 |
| Aromatase deficiency | 613546 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| disorder of sexual development | cyp19a1azf1031/zf1031 (AB) | standard conditions | Yin et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 Monooxygenases | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:O42145
|
509 | |||||
|
UniProtKB:Q1LV36
|
517 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp19a1a-201
(1)
|
Ensembl | 1,862 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB2-cyp19a1a | polyclonal | Rabbit |
|
1 | |||
| Ab1-cyp19a1a | polyclonal | IgG | Rabbit |
|
AnaSpec
|
4 |
Plasmids
No data available