Gene
vegfaa
- ID
- ZDB-GENE-990415-273
- Name
- vascular endothelial growth factor Aa
- Symbol
- vegfaa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Exhibits growth factor activity. Involved in several processes, including animal organ development; circulatory system development; and regulation of vasculature development. Predicted to localize to extracellular space. Used to study proteinuria. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); reproductive organ cancer (multiple); and retinal disease (multiple). Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; podocyte; and trunk. Orthologous to human VEGFA (vascular endothelial growth factor A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 114 figures from 93 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 47 figures from 27 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Microvascular complications of diabetes 1} | 603933 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| proteinuria | WT + MO10-vegfaa | standard conditions | Müller-Deile et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023581 | Platelet-derived growth factor, conserved site |
| Domain | IPR000072 | PDGF/VEGF domain |
| Domain | IPR027928 | Vascular endothelial growth factor, heparin-binding domain |
| Family | IPR050507 | Platelet-derived/Vascular endothelial growth factor |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
| Homologous_superfamily | IPR036841 | Vascular endothelial growth factor, heparin-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived/Vascular endothelial growth factor | Vascular endothelial growth factor, heparin-binding domain | Vascular endothelial growth factor, heparin-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AHS3
|
207 | ||||||
|
UniProtKB:O73682
|
188 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vegfaa-201
(1)
|
Ensembl | 2,658 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-vegfaa | polyclonal | IgG | Goat |
|
R&D Systems
|
2 |
Plasmids