Gene
fzd5
- ID
- ZDB-GENE-990415-218
- Name
- frizzled class receptor 5
- Symbol
- fzd5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits Wnt-activated receptor activity. Involved in animal organ development; negative regulation of canonical Wnt signaling pathway; and non-canonical Wnt signaling pathway. Predicted to localize to integral component of membrane and plasma membrane. Used to study coloboma. Is expressed in several structures, including endoderm; eye; gut; hematopoietic stem cell; and neural plate. Orthologous to human FZD5 (frizzled class receptor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microphthalmia/coloboma 11 | 620731 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | AB + MO3-fzd5 | standard conditions | Liu et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|
|
UniProtKB:B3DIG4
|
592 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Momoi, et al. (2003. Mech. Dev. 120:477-489.) reported this gene as fz8c with orthology to human FZD8 and mouse Fzd8 based on amino acid similarity. Subsequent analysis suggests this gene is fzd5 with orthology to human FZD5 and mouse Fzd5 based on amino acid similarity and conserved location.