Gene
pax7a
- ID
- ZDB-GENE-990415-201
- Name
- paired box 7a
- Symbol
- pax7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in developmental pigmentation; regulation of xanthophore differentiation; and wound healing. Localizes to nucleus. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Is expressed in several structures, including central nervous system; muscle; neural crest; neural tube; and post-vent region. Orthologous to human PAX7 (paired box 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 62 figures from 41 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma 2, alveolar | 268220 |
| congenital myopathy 19 | Alliance | Congenital myopathy 19 | 618578 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001523 | Paired domain |
| Domain | IPR003654 | OAR domain |
| Domain | IPR022106 | Paired box protein 7, C-terminal |
| Domain | IPR043182 | Paired DNA-binding domain |
| Family | IPR043565 | PAX family |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired box protein 7, C-terminal | Paired DNA-binding domain | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IM38
|
487 | |||||||||
|
UniProtKB:O57418
|
507 | |||||||||
|
UniProtKB:A0A8M3B4A0
|
502 |
Interactions and Pathways
No data available
Plasmids
No data available