Gene

mdm2

ID

ZDB-GENE-990415-153

Name

MDM2 proto-oncogene

Symbol

mdm2 Nomenclature History

Previous Names

etID309863.4 (1)
sb:eu923
zgc:109834

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blood; digestive system; head; mesoderm; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

83 figures from 65 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109834 (11 images)
eu923 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mdm2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Lessel-Kubisch syndrome	618681
		{Accelerated tumor formation, susceptibility to}	614401

Associated With mdm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR001876	Zinc finger, RanBP2-type
Domain	IPR003121	SWIB/MDM2 domain
Domain	IPR044080	MDM2, modified RING finger, HC subclass
Family	IPR016495	p53 negative regulator Mdm2/Mdm4
Family	IPR028340	E3 ubiquitin-protein ligase Mdm2
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily
Homologous_superfamily	IPR036885	SWIB/MDM2 domain superfamily

Domain Details Per Protein

Protein	Length	E3 ubiquitin-protein ligase Mdm2	MDM2, modified RING finger, HC subclass	p53 negative regulator Mdm2/Mdm4	SWIB/MDM2 domain	SWIB/MDM2 domain superfamily	Zinc finger, RanBP2-type	Zinc finger, RanBP2-type superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type
UniProtKB:O42354 InterPro PDB	445
UniProtKB:A0A8M2BC69 InterPro	486
UniProtKB:Q561Z0 InterPro	475

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mdm2-201 (1) Ensembl	Ensembl	1,965 nt	Select Tool ZFIN BLAST
mRNA	mdm2-202 (1) Ensembl	Ensembl	2,812 nt	Select Tool ZFIN BLAST
mRNA	mdm2-206 (1) Ensembl	Ensembl	584 nt	Select Tool ZFIN BLAST
mRNA	mdm2-208 (1) Ensembl	Ensembl	3,486 nt	Select Tool ZFIN BLAST
mRNA	mdm2-209 (1) Ensembl	Ensembl	911 nt	Select Tool ZFIN BLAST
ncRNA	mdm2-002 (1) Ensembl	Ensembl	642 nt	Select Tool ZFIN BLAST
ncRNA	mdm2-003 (1) Ensembl	Ensembl	294 nt	Select Tool ZFIN BLAST
ncRNA	mdm2-004 (1) Ensembl	Ensembl	607 nt	Select Tool ZFIN BLAST
ncRNA	mdm2-006 (1) Ensembl	Ensembl	400 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mdm2	polyclonal	mdm2	IgG	Rabbit	IHC	AnaSpec	4

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations