Gene
ret
- ID
- ZDB-GENE-980526-307
- Name
- ret proto-oncogene receptor tyrosine kinase
- Symbol
- ret Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables protein homodimerization activity. Acts upstream of or within several processes, including autonomic nervous system development; axon extension; and branchiomeric skeletal muscle development. Predicted to be located in membrane raft. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in nervous system; pharyngeal arch; presumptive enteric nervous system; pronephros; and vagal neural crest. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 13 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial medullary thyroid carcinoma | Alliance | Medullary thyroid carcinoma | 155240 |
| multiple endocrine neoplasia type 2A | Alliance | Multiple endocrine neoplasia IIA | 171400 |
| multiple endocrine neoplasia type 2B | Alliance | Multiple endocrine neoplasia IIB | 162300 |
| pheochromocytoma | Alliance | Pheochromocytoma | 171300 |
| {Hirschsprung disease, protection against} | 142623 | ||
| {Hirschsprung disease, susceptibility to, 1} | 142623 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Hirschsprung's disease | retwmr1/+; em2Tg/em2Tg | standard conditions | Baker et al., 2022 |
| Hirschsprung's disease | rethu2846/+ | standard conditions | Heanue et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR040667 | Tyrosine-protein kinase receptor Ret, cadherin like domain 3 |
| Domain | IPR041163 | Ret, cadherin like domain 1 |
| Domain | IPR041317 | RET, cadherin-like domain 4 |
| Family | IPR016249 | Tyrosine-protein kinase, Ret receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
Domain Details Per Protein
| Protein | Length | Cadherin-like | Cadherin-like superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Ret, cadherin like domain 1 | RET, cadherin-like domain 4 | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase receptor Ret, cadherin like domain 3 | Tyrosine-protein kinase, Ret receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8E7C6
|
1106 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ret | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
4 |
Plasmids
No data available