Gene
npr2
- ID
- ZDB-GENE-141030-2
- Name
- natriuretic peptide receptor 2
- Symbol
- npr2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Acts upstream of or within cardiac muscle cell proliferation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including fin; head; kidney; neural tube; and oocyte. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acromesomelic dysplasia, Maroteaux type | Alliance | Acromesomelic dysplasia 1, Maroteaux type | 602875 |
| Miura type epiphyseal chondrodysplasia | Alliance | Epiphyseal chondrodysplasia, Miura type | 615923 |
| Short stature with nonspecific skeletal abnormalities | 616255 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001828 | Receptor, ligand binding region |
| Family | IPR001170 | Adenylyl cyclase class-4/guanylyl cyclase |
| Family | IPR050401 | Cyclic nucleotide synthase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
| Homologous_superfamily | IPR029787 | Nucleotide cyclase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Cyclic nucleotide synthase | Nucleotide cyclase | Periplasmic binding protein-like I | Protein kinase domain | Protein kinase-like domain superfamily | Receptor, ligand binding region | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KGK2 | InterPro | 1043 | ||||||||||
| UniProtKB:A0A8M3B2U7 | InterPro | 1048 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available