Gene
glis2a
- ID
- ZDB-GENE-130102-1
- Name
- GLIS family zinc finger 2a
- Symbol
- glis2a Nomenclature History
- Previous Names
-
- znphp7.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in eye; gut; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kim et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramachandran et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephronophthisis 7 | Alliance | Nephronophthisis 7 | 611498 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2H2-type zinc-finger protein GLI-like | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:A0A8M9PQF1
|
395 | |||
|
UniProtKB:F1Q792
|
446 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
glis2a-201
(1)
|
Ensembl | 5,944 nt |
Interactions and Pathways
No data available
Plasmids
No data available