Gene
kcnt1a
- ID
- ZDB-GENE-091231-1
- Name
- potassium sodium-activated channel subfamily T member 1a
- Symbol
- kcnt1a Nomenclature History
- Previous Names
-
- kcnt1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have intracellular sodium activated potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transport. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and early infantile epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Silic et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nocturnal frontal lobe epilepsy 5 | Alliance | Epilepsy nocturnal frontal lobe, 5 | 615005 |
| developmental and epileptic encephalopathy 14 | Alliance | Developmental and epileptic encephalopathy 14 | 614959 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium-activated potassium channel BK, alpha subunit | Calcium-activated potassium channel slowpoke-like | NAD(P)-binding domain superfamily | Potassium channel domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ALW9
|
1173 | ||||
|
UniProtKB:A0A8M3AWL0
|
1172 | ||||
|
UniProtKB:A0A8M3ATL3
|
1159 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnt1-206
(1)
|
Ensembl | 3,264 nt | ||
| mRNA |
kcnt1a-201
(1)
|
Ensembl | 3,169 nt | ||
| mRNA |
kcnt1a-202
(1)
|
Ensembl | 3,378 nt | ||
| mRNA |
kcnt1a-204
(1)
|
Ensembl | 3,111 nt | ||
| mRNA |
kcnt1a-205
(1)
|
Ensembl | 3,336 nt |
Interactions and Pathways
No data available
Plasmids