Gene

alox5a

ID

ZDB-GENE-090311-47

Name

arachidonate 5-lipoxygenase a

Symbol

alox5a Nomenclature History

Previous Names

ALOX2 (1)
alox5
LOX2 (1)
si:dkey-194n13.2

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Exhibits arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Involved in arachidonic acid metabolic process. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Is expressed in pronephric duct. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma	Alliance	{Asthma, diminished response to antileukotriene treatment in}	600807
		{Atherosclerosis, susceptibility to}

Associated With alox5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020833	Lipoxygenase, iron binding site
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Domain	IPR042062	Lipoxygenase, vertebrates, PLAT domain
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily