Gene
hif1aa
- ID
- ZDB-GENE-080917-55
- Name
- hypoxia inducible factor 1 subunit alpha a
- Symbol
- hif1aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including Notch signaling pathway; hematopoietic stem cell differentiation; and macrophage migration. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in diabetic retinopathy; lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gerri et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR014887 | HIF-1 alpha, C-terminal transactivation domain |
| Domain | IPR021537 | Hypoxia-inducible factor, alpha subunit-like |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | HIF-1 alpha, C-terminal transactivation domain | Hypoxia-inducible factor, alpha subunit-like | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QNB9
|
717 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
hif1aa-202
(1)
|
Ensembl | 1,294 nt | ||
| mRNA |
hif1aa-201
(1)
|
Ensembl | 2,154 nt | ||
| mRNA |
hif1aa-203
(1)
|
Ensembl | 2,204 nt |
Interactions and Pathways
No data available
Plasmids
No data available