Gene

cyfip2

ID

ZDB-GENE-080724-2

Name

cytoplasmic FMR1 interacting protein 2

Symbol

cyfip2 Nomenclature History

Previous Names

nev (1)
nevermind (1)
zgc:194528

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Acts upstream of or within with a positive effect on retinal ganglion cell axon guidance. Acts upstream of or within retina layer formation and startle response. Predicted to be located in cytoplasm. Predicted to be active in neuron projection and synapse. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 65. Orthologous to human CYFIP2 (cytoplasmic FMR1 interacting protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyfip2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 65	Alliance	Developmental and epileptic encephalopathy 65	618008

Associated With cyfip2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009828	CYRIA/CYRIB, Rac1 binding domain
Family	IPR008081	Cytoplasmic FMR1-interacting

Domain Details Per Protein

Protein	Length	CYRIA/CYRIB, Rac1 binding domain	Cytoplasmic FMR1-interacting
UniProtKB:A0A8M3AS06 InterPro	1251
UniProtKB:A5A5E1 InterPro	1253
UniProtKB:B3DIT1 InterPro	1252
UniProtKB:A0A8M3AP56 InterPro	1016

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cyfip2-201 (1) Ensembl	Ensembl	4,023 nt	Select Tool ZFIN BLAST
mRNA	cyfip2-202 (1) Ensembl	Ensembl	5,369 nt	Select Tool ZFIN BLAST
mRNA	cyfip2-203 (1) Ensembl	Ensembl	3,762 nt	Select Tool ZFIN BLAST
mRNA	cyfip2-204 (1) Ensembl	Ensembl	6,797 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-cyfip2	polyclonal	cyfip2	IgG	Rabbit	IHC	Abcam plc	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations