Gene

hmx1

ID

ZDB-GENE-080204-54

Name

H6 family homeobox 1

Symbol

hmx1 Nomenclature History

Previous Names

im:7155045
nkx5-3 (1)
nkx5.3 (1)
zgc:172164

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in retinal cone cell development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Is expressed in immature eye; neural plate; otic vesicle; pharyngeal arch; and sensory system. Orthologous to human HMX1 (H6 family homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7155045 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
oculoauricular syndrome	Alliance	Oculoauricular syndrome	612109

Associated With hmx1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR051300	HMX Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily