Gene
atr
- ID
- ZDB-GENE-070912-458
- Name
- ATR serine/threonine kinase
- Symbol
- atr Nomenclature History
- Previous Names
-
- si:dkey-231j24.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in several processes, including determination of left/right symmetry; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of heart looping. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 1 and pancreatic cancer. Is expressed in hindbrain neural rod; midbrain neural rod; optic vesicle; somite; and tail bud. Orthologous to human ATR (ATR serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Stiff et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Seckel syndrome 1 | Alliance | Seckel syndrome 1 | 210600 |
| ?Cutaneous telangiectasia and cancer syndrome, familial | 614564 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003151 | PIK-related kinase, FAT |
| Domain | IPR003152 | FATC domain |
| Domain | IPR012993 | UME domain |
| Domain | IPR014009 | PIK-related kinase |
| Family | IPR050517 | DNA Damage Response and Repair Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Tetratricopeptide-like helical domain superfamily | UME domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P8M6
|
2077 | ||||||||||||
|
UniProtKB:A0A8N7TEF8
|
2633 |
Interactions and Pathways
No data available
Plasmids
No data available