Gene

sirt1

ID

ZDB-GENE-070801-2

Name

sirtuin 1

Symbol

sirt1 Nomenclature History

Previous Names

im:7148963

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have several functions, including NAD+ binding activity; p53 binding activity; and transcription corepressor activity. Involved in cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; and regulation of gliogenesis. Predicted to localize to chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Is expressed in female organism; liver; male organism; and retina. Orthologous to human SIRT1 (sirtuin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 14 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148963 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sirt1 Human Ortholog

No data available

Associated With sirt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR026590	Sirtuin family, catalytic core domain
Family	IPR003000	Sirtuin family
Family	IPR050134	NAD-dependent sirtuin protein deacylases
Homologous_superfamily	IPR026591	Sirtuin, catalytic core small domain superfamily
Homologous_superfamily	IPR029035	DHS-like NAD/FAD-binding domain superfamily

Domain Details Per Protein

Protein	Length	DHS-like NAD/FAD-binding domain superfamily	NAD-dependent sirtuin protein deacylases	Sirtuin, catalytic core small domain superfamily	Sirtuin family	Sirtuin family, catalytic core domain
UniProtKB:A0A8M2BKA6 InterPro	695
UniProtKB:E7F8W3 InterPro	710

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sirt1-201 (1) Ensembl	Ensembl		6,340 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-sirt1		sirt1		Rabbit		Aviva Systems Biology	2
Ab2-sirt1	polyclonal	sirt1		Rabbit	WB	Sigma-Aldrich	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations