Gene

cerkl

ID

ZDB-GENE-070410-38

Name

CERK like autophagy regulator

Symbol

cerkl Nomenclature History

Previous Names

zgc:162213

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have NAD+ kinase activity. Involved in several processes, including negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; regulation of apoptotic cell clearance; and retina layer formation. Localizes to cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 26. Is expressed in several structures, including eye; gill; heart; kidney; and optic cup. Orthologous to human CERKL (ceramide kinase like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cerkl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 26	Alliance	Retinitis pigmentosa 26	608380

Associated With cerkl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001206	Diacylglycerol kinase, catalytic domain
Domain	IPR045363	Ceramide kinase, C-terminal domain
Family	IPR050187	Lipid Phosphate Formation and Regulation
Homologous_superfamily	IPR016064	NAD kinase/diacylglycerol kinase-like domain superfamily
Homologous_superfamily	IPR017438	Inorganic polyphosphate/ATP-NAD kinase, N-terminal