Gene

esrp1

ID

ZDB-GENE-070112-1732

Name

epithelial splicing regulatory protein 1

Symbol

esrp1 Nomenclature History

Previous Names

rbm35a
wu:fi28a07
zgc:154050

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Is expressed in several structures, including digestive system; ectoderm; epidermis; median fin fold; and tail bud. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Burguera et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With esrp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 109	Alliance	?Deafness, autosomal recessive 109	618013

Associated With esrp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR013520	Exonuclease, RNase T/DNA polymerase III
Domain	IPR034427	ESRP1, RNA recognition motif 1
Family	IPR050666	Epithelial Splicing Regulatory
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily