Gene

fto

ID
ZDB-GENE-061108-1
Name
FTO alpha-ketoglutarate dependent dioxygenase
Symbol
fto Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have DNA-N1-methyladenine dioxygenase activity; demethylase activity; and ferrous iron binding activity. Involved in several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Osborn et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fto Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Growth retardation, developmental delay, facial dysmorphism 612938
{Obesity, susceptibility to, BMIQ14} 612460
Associated With fto Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR024366 Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Domain IPR024367 Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
Family IPR032868 Alpha-ketoglutarate-dependent dioxygenase FTO
Homologous_superfamily IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Homologous_superfamily IPR038413 FTO, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily Alpha-ketoglutarate-dependent dioxygenase FTO Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal FTO, C-terminal domain superfamily
UniProtKB:A0A8M1PZX3 579
UniProtKB:A0A8M9PKY4 580
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fto-201 (1) Ensembl 851 nt
mRNA fto-202 (1) Ensembl 3,353 nt
mRNA fto-203 (1) Ensembl 4,295 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fto monoclonal IgG Mouse
  • WB
PhosphoSolutions
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations