Gene
fto
- ID
- ZDB-GENE-061108-1
- Name
- FTO alpha-ketoglutarate dependent dioxygenase
- Symbol
- fto Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have DNA-N1-methyladenine dioxygenase activity; demethylase activity; and ferrous iron binding activity. Involved in several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Osborn et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR024366 | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal |
Domain | IPR024367 | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain |
Family | IPR032868 | Alpha-ketoglutarate-dependent dioxygenase FTO |
Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
Homologous_superfamily | IPR038413 | FTO, C-terminal domain superfamily |
Domain Details Per Protein
Protein | Length | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | Alpha-ketoglutarate-dependent dioxygenase FTO | Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain | Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal | FTO, C-terminal domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:A0A8M1PZX3
|
579 | |||||
UniProtKB:A0A8M9PKY4
|
580 |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-fto | monoclonal | IgG | Mouse |
|
PhosphoSolutions
|
1 |
Plasmids
No data available