Gene

fto

ID

ZDB-GENE-061108-1

Name

FTO alpha-ketoglutarate dependent dioxygenase

Symbol

fto Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have DNA-N1-methyladenine dioxygenase activity; demethylase activity; and ferrous iron binding activity. Involved in several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Osborn et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fto Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Growth retardation, developmental delay, facial dysmorphism	612938
		{Obesity, susceptibility to, BMIQ14}	612460

Associated With fto Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024366	Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Domain	IPR024367	Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
Family	IPR032868	Alpha-ketoglutarate-dependent dioxygenase FTO
Homologous_superfamily	IPR037151	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Homologous_superfamily	IPR038413	FTO, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily	Alpha-ketoglutarate-dependent dioxygenase FTO	Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain	Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal	FTO, C-terminal domain superfamily
UniProtKB:A0A8M1PZX3 InterPro	579
UniProtKB:A0A8M9PKY4 InterPro	580

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fto-201 (1) Ensembl	Ensembl	851 nt	Select Tool ZFIN BLAST
mRNA	fto-202 (1) Ensembl	Ensembl	3,353 nt	Select Tool ZFIN BLAST
mRNA	fto-203 (1) Ensembl	Ensembl	4,295 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fto	monoclonal	fto	IgG	Mouse	WB	PhosphoSolutions	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations