Gene

pi4kb

ID

ZDB-GENE-061013-96

Name

phosphatidylinositol 4-kinase, catalytic, beta

Symbol

pi4kb Nomenclature History

Previous Names

pik4cb (1)
PI4KIII-beta (1)
zgc:152715 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol 4-kinase activity. Involved in semicircular canal development. Predicted to localize to cytoplasm and membrane. Is expressed in brain; head; pharyngeal arch 3-7; and semicircular canal. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pi4kb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 87	Alliance	Deafness, autosomal dominant 87	620281

Associated With pi4kb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR049160	PI4KB/PIK1, accessory domain
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	Phosphatidylinositol kinase	Phosphoinositide 3-kinase, accessory (PIK) domain	PI4KB/PIK1, accessory domain	Protein kinase-like domain superfamily
UniProtKB:F1RBR8 InterPro	850
UniProtKB:A0A8M2B4L5 InterPro	848
UniProtKB:Q49GP3 InterPro	835

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pi4kb-201 (1) Ensembl	Ensembl	4,300 nt	Select Tool
mRNA	pi4kb-202 (1) Ensembl	Ensembl	614 nt	Select Tool
mRNA	pi4kb-203 (1) Ensembl	Ensembl	3,292 nt	Select Tool ZFIN BLAST
mRNA	pi4kb-204 (1) Ensembl	Ensembl	4,940 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pi4kb	monoclonal	pi4kb	IgG2a	Mouse	IHC	BD Biosciences	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations