Gene

lhx4

ID

ZDB-GENE-060728-1

Name

LIM homeobox 4

Symbol

lhx4 Nomenclature History

Previous Names

si:dkeyp-35f11.3

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within ventral spinal cord interneuron specification. Predicted to be active in nucleus. Is expressed in adenohypophyseal placode; nervous system; spinal cord neural keel; and spinal cord neural tube. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 4. Orthologous to human LHX4 (LIM homeobox 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from Roisman-Geller et al., 2024
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lhx4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined pituitary hormone deficiency 4	Alliance	Pituitary hormone deficiency, combined, 4	262700

Associated With lhx4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
combined pituitary hormone deficiency	lhx4^tlv12/tlv12	standard conditions	Roisman-Geller et al., 2024

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR047956	LIM/homeobox protein Lhx4, LIM domain 1
Domain	IPR049594	LIM/homeobox protein Lhx3/4-like, LIM domain 2
Family	IPR050453	LIM/homeobox transcription factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily