Gene

lhx4

ID

ZDB-GENE-060728-1

Name

LIM homeobox 4

Symbol

lhx4 Nomenclature History

Previous Names

si:dkeyp-35f11.3

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in ventral spinal cord interneuron specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism. Is expressed in adenohypophyseal placode; nervous system; spinal cord neural keel; and spinal cord neural tube. Orthologous to human LHX4 (LIM homeobox 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lhx4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypopituitarism	Alliance	Pituitary hormone deficiency, combined, 4	262700

Associated With lhx4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR001781	Zinc finger, LIM-type
Domain	IPR047956	LIM/homeobox protein Lhx4, LIM domain 1
Domain	IPR049594	LIM/homeobox protein Lhx3/4-like, LIM domain 2
Family	IPR050453	LIM/homeobox transcription factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily