Gene
acaca
- ID
- ZDB-GENE-060526-74
- Name
- acetyl-CoA carboxylase alpha
- Symbol
- acaca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; acetyl-CoA carboxylase activity; and metal ion binding activity. Involved in response to (R)-carnitine. Is expressed in liver and male organism. Orthologous to human ACACA (acetyl-CoA carboxylase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Acetyl-CoA carboxylase deficiency | 613933 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| Domain | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| Domain | IPR005482 | Biotin carboxylase, C-terminal |
| Domain | IPR011761 | ATP-grasp fold |
| Domain | IPR011762 | Acetyl-coenzyme A carboxyltransferase, N-terminal |
| Domain | IPR011763 | Acetyl-coenzyme A carboxyltransferase, C-terminal |
| Domain | IPR011764 | Biotin carboxylation domain |
| Domain | IPR013537 | Acetyl-CoA carboxylase, central domain |
| Domain | IPR034733 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta |
| Domain | IPR049074 | Acetyl-CoA carboxylase, BT domain |
| Family | IPR049076 | Acetyl-CoA carboxylase |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR011054 | Rudiment single hybrid motif |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
| Homologous_superfamily | IPR029045 | ClpP/crotonase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase, BT domain | Acetyl-CoA carboxylase, central domain | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | Acetyl-coenzyme A carboxyltransferase, C-terminal | Acetyl-coenzyme A carboxyltransferase, N-terminal | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | ClpP/crotonase-like domain superfamily | Pre-ATP-grasp domain superfamily | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZ52
|
2349 | ||||||||||||||||||
|
UniProtKB:A0A8M9PK80
|
2425 | ||||||||||||||||||
|
UniProtKB:A0A8M9QE20
|
2326 | ||||||||||||||||||
|
UniProtKB:A0A2R8QJA0
|
2375 | ||||||||||||||||||
|
UniProtKB:A0A8M9Q3F9
|
2348 | ||||||||||||||||||
|
UniProtKB:A0A8M6Z6X1
|
2368 | ||||||||||||||||||
|
UniProtKB:A0A8M6Z6C9
|
2341 | ||||||||||||||||||
|
UniProtKB:A0A8M9Q8Q1
|
2391 | ||||||||||||||||||
|
UniProtKB:F6P055
|
2383 | ||||||||||||||||||
|
UniProtKB:A0A8M9PK85
|
2383 | ||||||||||||||||||
|
UniProtKB:A0A8M9Q3F2
|
2418 | ||||||||||||||||||
|
UniProtKB:A0A8M1NZ82
|
2390 | ||||||||||||||||||
|
UniProtKB:A0A8M9QE14
|
2410 | ||||||||||||||||||
|
UniProtKB:A0A8M6YY91
|
2356 | ||||||||||||||||||
|
UniProtKB:A0A8M9PXQ3
|
2376 |
Interactions and Pathways
No data available
Plasmids
No data available