Gene

fras1

ID

ZDB-GENE-060526-68

Name

Fraser extracellular matrix complex subunit 1

Symbol

fras1 Nomenclature History

Previous Names

id:ibd5080
pif (1)
pinfin (1)
si:ch211-191a6.5
wu:fc10b09

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Acts upstream of or within several processes, including basement membrane organization; embryonic viscerocranium morphogenesis; and epithelial structure maintenance. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including median fin fold; mesoderm; nervous system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159429 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fras1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fraser syndrome 1	Alliance	Fraser syndrome 1	219000

Associated With fras1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Family	IPR051561	FRAS1-related extracellular matrix
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Repeat	IPR006212	Furin-like repeat
Repeat	IPR039005	CSPG repeat

Domain Details Per Protein

Protein	Length	CalX-like domain superfamily	CSPG repeat	EGF-like domain	FRAS1-related extracellular matrix	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	Na-Ca exchanger/integrin-beta4	VWFC domain
UniProtKB:F1Q633 InterPro	3970
UniProtKB:A0A8M9Q8W1 InterPro	3992
UniProtKB:A0A8M3AZT2 InterPro	4002
UniProtKB:A0A0R4IQJ3 InterPro	4003

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fras1-201 (1) Ensembl	Ensembl	11,913 nt	Select Tool ZFIN BLAST
mRNA	fras1-202 (1) Ensembl	Ensembl	11,970 nt	Select Tool ZFIN BLAST
mRNA	fras1-203 (1) Ensembl	Ensembl	12,999 nt	Select Tool ZFIN BLAST
mRNA	fras1-205 (1) Ensembl	Ensembl	12,268 nt	Select Tool ZFIN BLAST
ncRNA	fras1-002 (1) Ensembl	Ensembl	505 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fras1	polyclonal	fras1		Rabbit	IHC		5

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations