Gene
msh3
- ID
- ZDB-GENE-060526-307
- Name
- mutS homolog 3 (E. coli)
- Symbol
- msh3 Nomenclature History
- Previous Names
-
- si:dkey-56d12.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded DNA binding activity. Predicted to be involved in mismatch repair; mitotic recombination; and somatic recombination of immunoglobulin gene segments. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| endometrial cancer | Alliance | Endometrial carcinoma, somatic | 608089 |
| familial adenomatous polyposis 4 | Alliance | Familial adenomatous polyposis 4 | 617100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| Domain | IPR007695 | DNA mismatch repair protein MutS-like, N-terminal |
| Domain | IPR007696 | DNA mismatch repair protein MutS, core |
| Domain | IPR007860 | DNA mismatch repair protein MutS, connector domain |
| Domain | IPR007861 | DNA mismatch repair protein MutS, clamp |
| Family | IPR017261 | DNA mismatch repair protein MutS/MSH |
| Homologous_superfamily | IPR016151 | DNA mismatch repair protein MutS, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
| Homologous_superfamily | IPR036678 | MutS, connector domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair protein MutS, clamp | DNA mismatch repair protein MutS, connector domain | DNA mismatch repair protein MutS, core | DNA mismatch repair protein MutS, core domain superfamily | DNA mismatch repair protein MutS, C-terminal | DNA mismatch repair protein MutS-like, N-terminal | DNA mismatch repair protein MutS/MSH | DNA mismatch repair protein MutS, N-terminal | MutS, connector domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B2S9
|
1087 | ||||||||||
|
UniProtKB:A0A8M6Z0M9
|
736 | ||||||||||
|
UniProtKB:A2CEA8
|
1083 | ||||||||||
|
UniProtKB:A0A288CFS8
|
1085 |
Interactions and Pathways
No data available
Plasmids
No data available