Gene
slc12a10.2
- ID
- ZDB-GENE-060503-425
- Name
- solute carrier family 12 member 10, tandem duplicate 2
- Symbol
- slc12a10.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits sodium:chloride symporter activity. Involved in chloride transport; inorganic ion homeostasis; and sodium ion transport. Predicted to localize to apical plasma membrane. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Is expressed in several structures, including ball; eye; gonad; integument; and opercular flap. Orthologous to human SLC12A3 (solute carrier family 12 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Amino acid permease, N-terminal | Amino acid permease/ SLC12A domain | SLC12A transporter, C-terminal | SLC12A transporter family | Thiazide-sensitive Na-K-Cl co-transporter |
|---|---|---|---|---|---|---|
|
UniProtKB:Q1L963
|
998 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc12a10.2-201
(1)
|
Ensembl | 6,367 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-slc12a10.2 | polyclonal | Rabbit |
|
5 |
Plasmids
No data available