Gene

esco2

ID

ZDB-GENE-050913-156

Name

establishment of sister chromatid cohesion N-acetyltransferase 2

Symbol

esco2 Nomenclature History

Previous Names

loc157570
si:dkey-217m5.6
un-named hi2865
unm hi2865
zgc:111795 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable peptide-lysine-N-acetyltransferase activity. Acts upstream of or within several processes, including bone regeneration; fin regeneration; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Is expressed in digestive system; heart; nervous system; otic vesicle; and pectoral fin. Used to study Roberts syndrome. Human ortholog(s) of this gene implicated in Roberts syndrome. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111795 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With esco2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Roberts syndrome	Alliance	Roberts-SC phocomelia syndrome	268300
		Juberg-Hayward syndrome	216100

Associated With esco2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Roberts syndrome	esco2^{hi2865Tg/hi2865Tg}	standard conditions	Xu et al., 2013
Roberts syndrome	WT + MO1-esco2	standard conditions	(2)
Roberts syndrome	esco2^{hi2865Tg/hi2865Tg}	standard conditions	Percival et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR028005	N-acetyltransferase ESCO, zinc-finger
Domain	IPR028009	N-acetyltransferase ESCO, acetyl-transferase domain

Domain Details Per Protein

Protein	Length	N-acetyltransferase ESCO, acetyl-transferase domain	N-acetyltransferase ESCO, zinc-finger
UniProtKB:Q5SPR8 InterPro	609
UniProtKB:A0A8M2B7P6 InterPro	608

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	esco2-201 (1) Ensembl	Ensembl		2,339 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-esco2	polyclonal	esco2		Rabbit	WB		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations