Gene

vps11

ID

ZDB-GENE-050731-5

Name

VPS11 core subunit of CORVET and HOPS complexes

Symbol

vps11 Nomenclature History

Previous Names

unm_w66 (1)
zgc:112329 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within several processes, including habituation; melanocyte apoptotic process; and retina development in camera-type eye. Predicted to be located in cytoplasmic vesicle and vacuole. Predicted to be part of HOPS complex. Predicted to be active in endosome. Is expressed in brain; heart; immature eye; and retina. Used to study hypomyelinating leukoencephalopathy. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dystonia 32	Alliance	?Dystonia 32	619637
hypomyelinating leukodystrophy 12	Alliance	Leukodystrophy, hypomyelinating, 12	616683

Associated With vps11 Via Experimental Models

Human Disease	Fish	Conditions	Citations
hypomyelinating leukoencephalopathy	vps11^wsu3/wsu3 (AB)	standard conditions	Banerjee et al., 2022
hypomyelinating leukoencephalopathy	vps11^wsu1/wsu1 (AB)	standard conditions	Banerjee et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Domain	IPR024763	Vacuolar protein sorting protein 11, C-terminal
Family	IPR016528	Vacuolar protein sorting-associated protein 11
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat