Gene

smarcad1a

ID

ZDB-GENE-050522-499

Name

SNF2 related chromatin remodeling ATPase with DExD box 1a

Symbol

smarcad1a Nomenclature History

Previous Names

smarcad1
wu:fi25c01
zgc:113183

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to be involved in ATP-dependent chromatin remodeling and DNA double-strand break processing. Predicted to localize to site of double-strand break. Human ortholog(s) of this gene implicated in adermatoglyphia. Orthologous to human SMARCAD1 (SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Han et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smarcad1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adermatoglyphia	Alliance	Adermatoglyphia	136000
BASAN syndrome	Alliance	Basan syndrome	129200
		Huriez syndrome	181600

Associated With smarcad1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000330	SNF2, N-terminal
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR003892	Ubiquitin system component CUE
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR049730	SNF2/RAD5-like, C-terminal helicase domain
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR038718	SNF2-like, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	SNF2-like, N-terminal domain superfamily	SNF2, N-terminal	SNF2/RAD5-like, C-terminal helicase domain	UBA-like superfamily	Ubiquitin system component CUE
UniProtKB:B0R061 InterPro	972
UniProtKB:A0A8M1N6H2 InterPro	972

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	smarcad1a-201 (1) Ensembl	Ensembl	3,644 nt	Select Tool
mRNA	smarcad1a-202 (1) Ensembl	Ensembl	600 nt	Select Tool
mRNA	smarcad1a-203 (1) Ensembl	Ensembl	2,151 nt	Select Tool
ncRNA	smarcad1a-004 (1) Ensembl	Ensembl	491 nt	Select Tool
ncRNA	smarcad1a-005 (1) Ensembl	Ensembl	479 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations