Gene

c9

ID

ZDB-GENE-050522-442

Name

complement component 9

Symbol

c9 Nomenclature History

Previous Names

wu:fb60b05
wu:fd50e04
zgc:112272

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Involved in cellular response to estrogen stimulus. Predicted to localize to membrane attack complex. Human ortholog(s) of this gene implicated in age related macular degeneration 15 and complement component 9 deficiency. Is expressed in liver and yolk syncytial layer. Orthologous to human C9 (complement C9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112272 (5 images)
IMAGE:7140385 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With c9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
age related macular degeneration 15	Alliance	{Macular degeneration, age-related, 15, susceptibility to}	615591
complement component 9 deficiency	Alliance	C9 deficiency	613825

Associated With c9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020863	Membrane attack complex component/perforin domain, conserved site
Domain	IPR020864	Membrane attack complex component/perforin (MACPF) domain
Family	IPR001862	Membrane attack complex component/perforin/complement C9
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat