Gene
zap70
- ID
- ZDB-GENE-050522-257
- Name
- zeta chain of T cell receptor associated protein kinase 70
- Symbol
- zap70 Nomenclature History
- Previous Names
-
- TCR-α (1)
- zgc:110383
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease and severe combined immunodeficiency. Is expressed in gut. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 48 | Alliance | Immunodeficiency 48 | 269840 |
| Autoimmune disease, multisystem, infantile-onset, 2 | 617006 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035838 | SYK/ZAP-70, N-terminal SH2 domain |
| Family | IPR012234 | Tyrosine-protein kinase, non-receptor SYK/ZAP-70 |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR023420 | Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SYK/ZAP-70, N-terminal SH2 domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, non-receptor SYK/ZAP-70 | Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q503P3
|
604 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-zap70 | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
2 |
Plasmids
No data available