Gene

cdk10

ID

ZDB-GENE-050417-94

Name

cyclin dependent kinase 10

Symbol

cdk10 Nomenclature History

Previous Names

zgc:110252 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Exhibits kinase activity. Involved in histone phosphorylation; negative regulation of neuron apoptotic process; and neurogenesis. Predicted to localize to nucleus. Is expressed in brain; eye; liver; and pleuroperitoneal region. Orthologous to human CDK10 (cyclin dependent kinase 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110252 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Yeh et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdk10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Al Kaissi syndrome	617694

Associated With cdk10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR044093	Cyclin-dependent kinase 10, catalytic domain
Family	IPR050108	Cyclin-dependent kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Cyclin-dependent kinase	Cyclin-dependent kinase 10, catalytic domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M3AWS0 InterPro	288
UniProtKB:F1QKU6 InterPro	360
UniProtKB:A0A8M3AZU9 InterPro	340

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cdk10-201 (1) Ensembl	Ensembl	1,655 nt	Select Tool
ncRNA	cdk10-002 (1) Ensembl	Ensembl	467 nt	Select Tool
ncRNA	cdk10-003 (1) Ensembl	Ensembl	534 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-cdk10	polyclonal	cdk10	IgG	Goat		Santa Cruz Biotechnology, Inc.	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations