Gene

akr1a1b

ID

ZDB-GENE-050417-118

Name

aldo-keto reductase family 1, member A1b (aldehyde reductase)

Symbol

akr1a1b Nomenclature History

Previous Names

zgc:110225 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Enables aldo-keto reductase (NADP) activity. Involved in glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110225 (1 image)
IMAGE:7154417 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Li et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With akr1a1b Human Ortholog

No data available

Associated With akr1a1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018170	Aldo/keto reductase, conserved site
Domain	IPR023210	NADP-dependent oxidoreductase domain
Family	IPR020471	Aldo-keto reductase
Family	IPR044481	Aldo-keto reductase family 1 member A1
Homologous_superfamily	IPR036812	NADP-dependent oxidoreductase domain superfamily

Domain Details Per Protein

Protein	Length	Aldo-keto reductase	Aldo/keto reductase, conserved site	Aldo-keto reductase family 1 member A1	NADP-dependent oxidoreductase domain	NADP-dependent oxidoreductase domain superfamily
UniProtKB:Q568L5 InterPro	324
UniProtKB:A0A8M2BDN5 InterPro	351
UniProtKB:A0A8M2BDV8 InterPro	326

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	akr1a1b-201 (1) Ensembl	Ensembl	754 nt	Select Tool ZFIN BLAST
mRNA	akr1a1b-202 (1) Ensembl	Ensembl	1,091 nt	Select Tool ZFIN BLAST
mRNA	akr1a1b-203 (1) Ensembl	Ensembl	910 nt	Select Tool ZFIN BLAST
mRNA	akr1a1b-204 (1) Ensembl	Ensembl	760 nt	Select Tool ZFIN BLAST
mRNA	akr1a1b-205 (1) Ensembl	Ensembl	1,182 nt	Select Tool ZFIN BLAST
mRNA	akr1a1b-207 (1) Ensembl	Ensembl	803 nt	Select Tool ZFIN BLAST
ncRNA	akr1a1b-007 (1) Ensembl	Ensembl	877 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-akr1a1b	polyclonal	akr1a1b		Guinea pig	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations