Gene

mstna

ID

ZDB-GENE-050208-735

Name

myostatin a

Symbol

mstna Nomenclature History

Previous Names

mstn2 (1)
gdf8l
myostatin-2 (1)
si:dkeyp-84a8.5
zfMSTN-2 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have cytokine activity. Involved in immune response. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Is expressed in several structures, including digestive system; eye; heart; muscle; and pleuroperitoneal region. Orthologous to human MSTN (myostatin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Wang et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mstna Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myostatin-related muscle hypertrophy	Alliance	?Muscle hypertrophy	614160

Associated With mstna Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine