Gene

shoc2

ID

ZDB-GENE-050208-523

Name

SHOC2 leucine rich repeat scaffold protein

Symbol

shoc2 Nomenclature History

Previous Names

si:ch211-159c12.3
si:ch211-197i12.3
zgc:152956

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have protein phosphatase binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction. Predicted to localize to nucleus and protein phosphatase type 1 complex. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Jang et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from Jang et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With shoc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Noonan syndrome-like disorder with loose anagen hair 1	Alliance	Noonan syndrome-like with loose anagen hair 1	607721

Associated With shoc2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
RASopathy	shoc2^{uky102/uky102}	standard conditions	Jang et al., 2018
Noonan syndrome-like disorder with loose anagen hair	shoc2^{uky101/uky101}	standard conditions	Jang et al., 2018
Noonan syndrome-like disorder with loose anagen hair	WT + MO1-shoc2	standard conditions	Jang et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR050216	Leucine-rich repeat domain-containing protein
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype