Gene
myo3a
- ID
- ZDB-GENE-041026-4
- Name
- myosin IIIA
- Symbol
- myo3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ATP binding activity; actin binding activity; and motor activity. Predicted to be involved in protein phosphorylation. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 30. Is expressed in axis; notochord; photoreceptor inner segment layer; polster; and retina. Orthologous to human MYO3A (myosin IIIA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu463 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 90 | Alliance | Deafness, autosomal dominant 90 | 620722 |
| autosomal recessive nonsyndromic deafness 30 | Alliance | Deafness, autosomal recessive 30 | 607101 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR036083 | Class III myosin, motor domain |
| Family | IPR052409 | Myosin-III family with kinase activity |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class III myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin-III family with kinase activity | P-loop containing nucleoside triphosphate hydrolase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90XG6
|
1775 |
Interactions and Pathways
No data available
Plasmids
No data available