Gene
myo3a
- ID
- ZDB-GENE-041026-4
- Name
- myosin IIIA
- Symbol
- myo3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable microfilament motor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; positive regulation of filopodium assembly; and sensory perception of sound. Predicted to act upstream of or within protein phosphorylation and visual perception. Predicted to be part of myosin complex. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Is expressed in axis; notochord; photoreceptor inner segment layer; polster; and retina. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (myosin IIIA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu463 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 90 | Alliance | Deafness, autosomal dominant 90 | 620722 |
| autosomal recessive nonsyndromic deafness 30 | Alliance | Deafness, autosomal recessive 30 | 607101 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR036083 | Class III myosin, motor domain |
| Family | IPR052409 | Myosin-III family with kinase activity |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class III myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin-III family with kinase activity | P-loop containing nucleoside triphosphate hydrolase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90XG6
|
1775 |
Interactions and Pathways
No data available
Plasmids
No data available